[Excess mortality associated with influenza in Spain in winter 2012].
Identifieur interne : 000163 ( Main/Exploration ); précédent : 000162; suivant : 000164[Excess mortality associated with influenza in Spain in winter 2012].
Auteurs : Inmaculada Le N-G Mez [Espagne] ; Concepci N Delgado-Sanz [Espagne] ; Silvia Jiménez-Jorge [Espagne] ; Víctor Flores [Espagne] ; Fernando Sim N [Espagne] ; Diana G Mez-Barroso [Espagne] ; Amparo Larrauri [Espagne] ; Salvador De Mateo Onta N [Espagne]Source :
- Gaceta sanitaria [ 1578-1283 ]
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Cause de décès (MeSH), Espagne (épidémiologie), Europe (épidémiologie), Grippe humaine (mortalité), Humains (MeSH), Modèles théoriques (MeSH), Mortalité (tendances), Pneumopathie infectieuse (mortalité), Répartition par âge (MeSH), Saisons (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Sous-type H3N2 du virus de la grippe A (MeSH), Sujet âgé (MeSH), Surveillance de la population (MeSH), Troubles respiratoires (mortalité), Épidémies de maladies (MeSH).
- MESH :
- mortalité : Grippe humaine, Pneumopathie infectieuse, Troubles respiratoires.
- tendances : Mortalité.
- épidémiologie : Espagne, Europe.
- Adulte d'âge moyen, Cause de décès, Humains, Modèles théoriques, Répartition par âge, Saisons, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sujet âgé, Surveillance de la population, Épidémies de maladies.
English descriptors
- KwdEn :
- Age Distribution (MeSH), Aged (MeSH), Cause of Death (MeSH), Disease Outbreaks (MeSH), Europe (epidemiology), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza A Virus, H3N2 Subtype (MeSH), Influenza, Human (mortality), Middle Aged (MeSH), Models, Theoretical (MeSH), Mortality (trends), Pneumonia (mortality), Population Surveillance (MeSH), Respiration Disorders (mortality), Seasons (MeSH), Spain (epidemiology).
- MESH :
- epidemiology : Europe, Spain.
- mortality : Influenza, Human, Pneumonia, Respiration Disorders.
- trends : Mortality.
- Age Distribution, Aged, Cause of Death, Disease Outbreaks, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Middle Aged, Models, Theoretical, Population Surveillance, Seasons.
Abstract
OBJECTIVE
An excess of mortality was detected in Spain in February and March 2012 by the Spanish daily mortality surveillance system and the «European monitoring of excess mortality for public health action» program. The objective of this article was to determine whether this excess could be attributed to influenza in this period.
METHODS
Excess mortality from all causes from 2006 to 2012 were studied using time series in the Spanish daily mortality surveillance system, and Poisson regression in the European mortality surveillance system, as well as the FluMOMO model, which estimates the mortality attributable to influenza. Excess mortality due to influenza and pneumonia attributable to influenza were studied by a modification of the Serfling model. To detect the periods of excess, we compared observed and expected mortality.
RESULTS
In February and March 2012, both the Spanish daily mortality surveillance system and the European mortality surveillance system detected a mortality excess of 8,110 and 10,872 deaths (mortality ratio (MR): 1.22 (95% CI:1.21-1.23) and 1.32 (95% CI: 1.29-1.31), respectively). In the 2011-12 season, the FluMOMO model identified the maximum percentage (97%) of deaths attributable to influenza in people older than 64 years with respect to the mortality total associated with influenza (13,822 deaths). The rate of excess mortality due to influenza and pneumonia and respiratory causes in people older than 64 years, obtained by the Serfling model, also reached a peak in the 2011-2012 season: 18.07 and 77.20, deaths per 100,000 inhabitants, respectively.
CONCLUSION
A significant increase in mortality in elderly people in Spain was detected by the Spanish daily mortality surveillance system and by the European mortality surveillance system in the winter of 2012, coinciding with a late influenza season, with a predominance of the A(H3N2) virus, and a cold wave in Spain. This study suggests that influenza could have been one of the main factors contributing to the mortality excess observed in the winter of 2012 in Spain.
DOI: 10.1016/j.gaceta.2015.01.011
PubMed: 25770916
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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CIBER de Epidemiología y Salud Pública (CIBERESP), España. Electronic address: ileon@isciii.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author><author><name sortKey="Delgado Sanz, Concepci N" sort="Delgado Sanz, Concepci N" uniqKey="Delgado Sanz C" first="Concepci N" last="Delgado-Sanz">Concepci N Delgado-Sanz</name><affiliation wicri:level="1"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author><author><name sortKey="Jimenez Jorge, Silvia" sort="Jimenez Jorge, Silvia" uniqKey="Jimenez Jorge S" first="Silvia" last="Jiménez-Jorge">Silvia Jiménez-Jorge</name><affiliation wicri:level="1"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author><author><name sortKey="Flores, Victor" sort="Flores, Victor" uniqKey="Flores V" first="Víctor" last="Flores">Víctor Flores</name><affiliation wicri:level="3"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Sim N, Fernando" sort="Sim N, Fernando" uniqKey="Sim N F" first="Fernando" last="Sim N">Fernando Sim N</name><affiliation wicri:level="1"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author><author><name sortKey="G Mez Barroso, Diana" sort="G Mez Barroso, Diana" uniqKey="G Mez Barroso D" first="Diana" last="G Mez-Barroso">Diana G Mez-Barroso</name><affiliation wicri:level="1"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author><author><name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name><affiliation wicri:level="1"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author><author><name sortKey="De Mateo Onta N, Salvador" sort="De Mateo Onta N, Salvador" uniqKey="De Mateo Onta N S" first="Salvador" last="De Mateo Onta N">Salvador De Mateo Onta N</name><affiliation wicri:level="1"><nlm:affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:regionArea><wicri:noRegion>España; CIBER de Epidemiología y Salud Pública (CIBERESP)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gaceta sanitaria</title><idno type="eISSN">1578-1283</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Distribution (MeSH)</term><term>Aged (MeSH)</term><term>Cause of Death (MeSH)</term><term>Disease Outbreaks (MeSH)</term><term>Europe (epidemiology)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza A Virus, H3N2 Subtype (MeSH)</term><term>Influenza, Human (mortality)</term><term>Middle Aged (MeSH)</term><term>Models, Theoretical (MeSH)</term><term>Mortality (trends)</term><term>Pneumonia (mortality)</term><term>Population Surveillance (MeSH)</term><term>Respiration Disorders (mortality)</term><term>Seasons (MeSH)</term><term>Spain (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Cause de décès (MeSH)</term><term>Espagne (épidémiologie)</term><term>Europe (épidémiologie)</term><term>Grippe humaine (mortalité)</term><term>Humains (MeSH)</term><term>Modèles théoriques (MeSH)</term><term>Mortalité (tendances)</term><term>Pneumopathie infectieuse (mortalité)</term><term>Répartition par âge (MeSH)</term><term>Saisons (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term><term>Sous-type H3N2 du virus de la grippe A (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Surveillance de la population (MeSH)</term><term>Troubles respiratoires (mortalité)</term><term>Épidémies de maladies (MeSH)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Europe</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term><term>Pneumonia</term><term>Respiration Disorders</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term><term>Pneumopathie infectieuse</term><term>Troubles respiratoires</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Mortalité</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Mortality</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Europe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Distribution</term><term>Aged</term><term>Cause of Death</term><term>Disease Outbreaks</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Middle Aged</term><term>Models, Theoretical</term><term>Population Surveillance</term><term>Seasons</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Cause de décès</term><term>Humains</term><term>Modèles théoriques</term><term>Répartition par âge</term><term>Saisons</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sujet âgé</term><term>Surveillance de la population</term><term>Épidémies de maladies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>An excess of mortality was detected in Spain in February and March 2012 by the Spanish daily mortality surveillance system and the «European monitoring of excess mortality for public health action» program. The objective of this article was to determine whether this excess could be attributed to influenza in this period.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Excess mortality from all causes from 2006 to 2012 were studied using time series in the Spanish daily mortality surveillance system, and Poisson regression in the European mortality surveillance system, as well as the FluMOMO model, which estimates the mortality attributable to influenza. Excess mortality due to influenza and pneumonia attributable to influenza were studied by a modification of the Serfling model. To detect the periods of excess, we compared observed and expected mortality.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In February and March 2012, both the Spanish daily mortality surveillance system and the European mortality surveillance system detected a mortality excess of 8,110 and 10,872 deaths (mortality ratio (MR): 1.22 (95% CI:1.21-1.23) and 1.32 (95% CI: 1.29-1.31), respectively). In the 2011-12 season, the FluMOMO model identified the maximum percentage (97%) of deaths attributable to influenza in people older than 64 years with respect to the mortality total associated with influenza (13,822 deaths). The rate of excess mortality due to influenza and pneumonia and respiratory causes in people older than 64 years, obtained by the Serfling model, also reached a peak in the 2011-2012 season: 18.07 and 77.20, deaths per 100,000 inhabitants, respectively.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>A significant increase in mortality in elderly people in Spain was detected by the Spanish daily mortality surveillance system and by the European mortality surveillance system in the winter of 2012, coinciding with a late influenza season, with a predominance of the A(H3N2) virus, and a cold wave in Spain. This study suggests that influenza could have been one of the main factors contributing to the mortality excess observed in the winter of 2012 in Spain.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25770916</PMID><DateCompleted><Year>2017</Year><Month>03</Month><Day>03</Day></DateCompleted><DateRevised><Year>2017</Year><Month>03</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1578-1283</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>4</Issue><PubDate><MedlineDate>2015 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>Gaceta sanitaria</Title><ISOAbbreviation>Gac Sanit</ISOAbbreviation></Journal><ArticleTitle>[Excess mortality associated with influenza in Spain in winter 2012].</ArticleTitle><Pagination><MedlinePgn>258-65</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gaceta.2015.01.011</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0213-9111(15)00015-1</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">An excess of mortality was detected in Spain in February and March 2012 by the Spanish daily mortality surveillance system and the «European monitoring of excess mortality for public health action» program. The objective of this article was to determine whether this excess could be attributed to influenza in this period.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Excess mortality from all causes from 2006 to 2012 were studied using time series in the Spanish daily mortality surveillance system, and Poisson regression in the European mortality surveillance system, as well as the FluMOMO model, which estimates the mortality attributable to influenza. Excess mortality due to influenza and pneumonia attributable to influenza were studied by a modification of the Serfling model. To detect the periods of excess, we compared observed and expected mortality.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In February and March 2012, both the Spanish daily mortality surveillance system and the European mortality surveillance system detected a mortality excess of 8,110 and 10,872 deaths (mortality ratio (MR): 1.22 (95% CI:1.21-1.23) and 1.32 (95% CI: 1.29-1.31), respectively). In the 2011-12 season, the FluMOMO model identified the maximum percentage (97%) of deaths attributable to influenza in people older than 64 years with respect to the mortality total associated with influenza (13,822 deaths). The rate of excess mortality due to influenza and pneumonia and respiratory causes in people older than 64 years, obtained by the Serfling model, also reached a peak in the 2011-2012 season: 18.07 and 77.20, deaths per 100,000 inhabitants, respectively.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">A significant increase in mortality in elderly people in Spain was detected by the Spanish daily mortality surveillance system and by the European mortality surveillance system in the winter of 2012, coinciding with a late influenza season, with a predominance of the A(H3N2) virus, and a cold wave in Spain. This study suggests that influenza could have been one of the main factors contributing to the mortality excess observed in the winter of 2012 in Spain.</AbstractText><CopyrightInformation>Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>León-Gómez</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España. Electronic address: ileon@isciii.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delgado-Sanz</LastName><ForeName>Concepción</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiménez-Jorge</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flores</LastName><ForeName>Víctor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simón</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Barroso</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larrauri</LastName><ForeName>Amparo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Mateo Ontañón</LastName><ForeName>Salvador</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.</Affiliation></AffiliationInfo></Author></AuthorList><Language>spa</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Exceso de mortalidad relacionado con la gripe en España en el invierno de 2012.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Gac Sanit</MedlineTA><NlmUniqueID>8901623</NlmUniqueID><ISSNLinking>0213-9111</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N">Europe</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008962" MajorTopicYN="N">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009026" MajorTopicYN="N">Mortality</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011014" MajorTopicYN="N">Pneumonia</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011159" MajorTopicYN="N">Population Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012120" MajorTopicYN="N">Respiration Disorders</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Gripe</Keyword><Keyword MajorTopicYN="Y">Influenza</Keyword><Keyword MajorTopicYN="Y">Invierno</Keyword><Keyword MajorTopicYN="Y">Mortalidad</Keyword><Keyword MajorTopicYN="Y">Mortality</Keyword><Keyword MajorTopicYN="Y">Poisson regression</Keyword><Keyword MajorTopicYN="Y">Public health surveillance</Keyword><Keyword MajorTopicYN="Y">Regresión de Poisson</Keyword><Keyword MajorTopicYN="Y">Serfling</Keyword><Keyword MajorTopicYN="Y">Series temporales</Keyword><Keyword MajorTopicYN="Y">Time series</Keyword><Keyword MajorTopicYN="Y">Vigilancia en salud pública</Keyword><Keyword MajorTopicYN="Y">Winter</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>01</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>01</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25770916</ArticleId><ArticleId IdType="pii">S0213-9111(15)00015-1</ArticleId><ArticleId IdType="doi">10.1016/j.gaceta.2015.01.011</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><noRegion><name sortKey="Le N G Mez, Inmaculada" sort="Le N G Mez, Inmaculada" uniqKey="Le N G Mez I" first="Inmaculada" last="Le N-G Mez">Inmaculada Le N-G Mez</name></noRegion><name sortKey="De Mateo Onta N, Salvador" sort="De Mateo Onta N, Salvador" uniqKey="De Mateo Onta N S" first="Salvador" last="De Mateo Onta N">Salvador De Mateo Onta N</name><name sortKey="Delgado Sanz, Concepci N" sort="Delgado Sanz, Concepci N" uniqKey="Delgado Sanz C" first="Concepci N" last="Delgado-Sanz">Concepci N Delgado-Sanz</name><name sortKey="Flores, Victor" sort="Flores, Victor" uniqKey="Flores V" first="Víctor" last="Flores">Víctor Flores</name><name sortKey="G Mez Barroso, Diana" sort="G Mez Barroso, Diana" uniqKey="G Mez Barroso D" first="Diana" last="G Mez-Barroso">Diana G Mez-Barroso</name><name sortKey="Jimenez Jorge, Silvia" sort="Jimenez Jorge, Silvia" uniqKey="Jimenez Jorge S" first="Silvia" last="Jiménez-Jorge">Silvia Jiménez-Jorge</name><name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name><name sortKey="Sim N, Fernando" sort="Sim N, Fernando" uniqKey="Sim N F" first="Fernando" last="Sim N">Fernando Sim N</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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